Learn about Prilosec (Omeprazole) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. 20 mg PO once daily for 4 to 8 weeks. If a patient does not respond to 8 weeks of treatment, an additional 4 weeks of treatment may be given. If there is recurrence of erosive esophagitis, additional 4 to 8 week courses of omeprazole may be considered. Consumer information about the OTC and prescription drug omeprazole (Prilosec, Zegerid Prilosec OTC, Zegerid OTC) used for treating acid-induced inflammation and ulcers of the stomach and duodenum, gastroesophageal reflux disease (GERD), heartburn, and Zollinger-Ellison Syndrome. Omeprazole can be used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcers, erosive esophagitis, Zollinger-Ellison syndrome, and eosinophilic esophagitis. Omeprazole and Sodium Bicarbonate Capsule official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Posology in adults. Treatment of duodenal ulcers. The recommended dose in patients with an active duodenal ulcer is omeprazole 20 mg once daily. In most patients healing occurs within two weeks. Advice and warnings for the use of Omeprazole during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out Correspondence from The New England Journal of Medicine — Gynecomastia during Omeprazole Therapy It's usual to take omeprazole once a day, first thing in the morning. It doesn't upset the stomach, so you can take it with or without food. If you take omeprazole twice a day, take 1 dose in the morning and 1 dose in the evening. Omeprazole, approved by the FDA, is available as a prescription and over-the-counter (OTC) drug used as a treatment for frequent heartburn. Learn about side effects, drug interactions, dosages, warnings, and more.